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Proteolysis-resistant human VEGF for wound healing (09 BE 0324 3E58)
A new human VEGF-A (Vascular Endothelial Growth Factor) isoform, VEGF111, has been cloned by a Belgian research team. Recombinant VEGF111 retains full biological activity and is resistant to proteolysis and wound fluid exudates collected from chronic ulcers. Due to these properties, VEGF111 could find application in dermatology, especially in wound healing. License or collaborative research agreement for further development, i.e. in vivo testing, are sought.
Country: Belgium
Type: OFFER
Date: 26.07.2010
VEGF is a potent angiogenic factor that stimulates vascular endothelial cell survival, proliferation, migration and differentiation. By inducing vascularisation, VEGF plays a pivotal role in the angiogenesis process during tissue reparation. As defective vascularisation is a significant medical problem in many disciplines, including wound healing, VEGF use has previously been investigated for the treatment of burns and wounds. However, wounds are rich in proteolytic enzymes, such as plasmin and matrix metalloproteinases, able to degrade classical VEGF isoforms. Proteolytic degradation of VEGF in chronic wounds is regarded as one of the reasons of unsatisfactory amelioration of healing.
Innovative Aspects:
A Belgian research team cloned a new isoform of VEGF-A, VEGF111, lacking the sequence encoded by exons 5-7. Recombinant VEGF111 retains full biological activity and is resistant to proteolytic degradation by plasmin and wound fluid exsudates collected from chronic ulcers.
Due to these properties, VEGF111 could overcome limitations due to VEGF sensitivity to proteolysis and find application in dermatology, specially in wound healing
Degree of development:
Patents/Rights: Patent(s) applied for but not yet granted
Requested Cooperation: License Agreement, Joint further development, Testing of new applications, Adaptation to specific needs
- Type of partner sought: research collaboration or license agreement
- Specific area of activity of the partner: dermatology, wound healing, pansement, dressing
- Task to be performed by the partner sought: in vivo testing
Type of Organisation:
Status: NEW
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