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Regulating Cholinergic Receptors (10 US 87GA 3GQG)
A Fortune (US) 100 company, invites proposals for altering (regulating) signal transduction cascades involving muscarinic or nicotinic receptors.
Country: United States
Type: REQUEST
Date: 05.03.2010
Many individuals are increasingly taking multiple medications for various ailments. These medications often produce undesired side effects, including, but not limited to: mood swings, changes in appetite, lethargy, headaches, altered sleeping patterns, bladder sensitivity, oral dryness and taste modifications. Our client seeks technologies, safe for human use, which would act on muscarinic or nicotinic receptors to bring back the natural function of these body systems or alleviate side effects of medication.
The successful technology will:
" Reversibly interact with muscarinic or nicotinic receptors
- Able to demonstrate interaction in vitro" Offer short term stability in a biological environment" Preferably be a natural ingredient1 or generally recognized as safe2 (GRAS)" Be safe for daily human use (contact)" Address the following time scales:
- Rapid onset
- Long acting, >60 min
- Ideally deliver sustained effect up to 4 hrs
Technical Specifications / Specific technical requirements:
APPROACHES NOT OF INTEREST
The following approaches are not of interest:" Enzymatic approaches" Technologies with unknown safety profile" Technologies lasting less than 2 hours
Degree of development:
Patents/Rights:
Requested Cooperation: License Agreement, Joint further development, Testing of new applications, Adaptation to specific needs
APPROPRIATE RESPONSES TO THIS REQUEST
Responses from companies (small to large), academic researchers, other research institutes, consultants, venture capitalists, entrepreneurs, or inventors are welcome. For example:
I am a company or academic person with technology which should provide a solution ready for testing and transfer to commercial use.
I am a company or academic person with technology which should provide a solution but that requires further research and development to ready it for transfer to commercial use.
Type of Organisation:
Status: NEW
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